It is now widely recognized that dynamic coordination among groups of neurons in local and long-range circuits is critical for orchestration of behavior.1 This is especially relevant to the biological basis of psychiatric illnesses where behavior is the primary measure for determining the presence or severity of symptoms. Much of the focus in biological psychiatry has been on establishing a link between symptoms and either morphological abnormalities or altered expression of receptors or other proteins involved in neural communication. A recent line of thinking, however, posits that the mechanisms that lead to behavioral symptoms may not have a static anatomical or cellular basis but are caused by transient disruptions in the coordinated activity of ensembles of neurons.
Moghaddam B, Wood J. Teamwork MattersCoordinated Neuronal Activity in Brain Systems Relevant to Psychiatric Disorders. JAMA Psychiatry. 2014;71(2):197-199. doi:10.1001/jamapsychiatry.2013.2080