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To the Editor Aberg et al1 in this journal present an important 2-stage study of schizophrenia. The replication study in stage 2 uses discordant sibling pairs, parent-child trios, and other families from multiple sources to study single-nucleotide polymorphisms (SNPs) from the stage 1 genome-wide meta-analysis. The most compelling statistic2 is that the direction of 89% of the odds ratios (ORs) agreed with the original meta-analysis in SNPs reaching P < .01 (sign test, P < 2.2 × 10−16). In this letter, I address concerns regarding the interpretation of the replication results.
Lazzeroni LC. Evaluating the Evidence of Replication for Genetic Associations With Schizophrenia. JAMA Psychiatry. 2014;71(1):94-95. doi:10.1001/jamapsychiatry.2013.2987