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Comment & Response
February 2014

Early Medication Discontinuation on Long-term Recovery Outcome in First-Episode Psychosis

Author Affiliations
  • 1Bipolar Disorders Unit, Neuroscience Institute, Hospital Clinic of Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Catalonia, Spain
JAMA Psychiatry. 2014;71(2):206-207. doi:10.1001/jamapsychiatry.2013.2993

To the Editor We read with interest the recently published study by Wunderink et al1 in this journal. It confirms previous evidence that drug-naive patients may respond to doses of antipsychotic medication at the lower end of the recommended range2 and goes further suggesting that patients in the dose reduction/discontinuation (DR) group have better long-term functional outcomes. Nevertheless, there are several methodological issues regarding that study as highlighted next.

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