To the Editor We read with interest the recently published study by Wunderink et al1 in this journal. It confirms previous evidence that drug-naive patients may respond to doses of antipsychotic medication at the lower end of the recommended range2 and goes further suggesting that patients in the dose reduction/discontinuation (DR) group have better long-term functional outcomes. Nevertheless, there are several methodological issues regarding that study as highlighted next.
Undurraga J, Murru A, Vieta E. Early Medication Discontinuation on Long-term Recovery Outcome in First-Episode Psychosis. JAMA Psychiatry. 2014;71(2):206-207. doi:10.1001/jamapsychiatry.2013.2993