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In Reply Undurraga et al comment on 3 methodological issues they perceived in our article.1 First, they state that both interventions were similar because ultimately only a small number of patients discontinued treatment and the mean doses used were arguably significantly different.
Second, Undurraga et al suggest functional outcomes could also be explained by baseline differences; they mention no blinding of the primary outcome and a subjective and unreliable outcome measure (Groningen Social Disabilities Schedule II).
Wunderink L, Sytema S. Early Medication Discontinuation on Long-term Recovery Outcome in First-Episode Psychosis—Reply. JAMA Psychiatry. 2014;71(2):208-209. doi:10.1001/jamapsychiatry.2013.3530