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Comment & Response
February 2014

Early Medication Discontinuation on Long-term Recovery Outcome in First-Episode Psychosis—Reply

Author Affiliations
  • 1Department of Research and Education, Friesland Mental Health Services, Leeuwarden, the Netherlands
  • 2Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
JAMA Psychiatry. 2014;71(2):208-209. doi:10.1001/jamapsychiatry.2013.3530

In Reply Undurraga et al comment on 3 methodological issues they perceived in our article.1 First, they state that both interventions were similar because ultimately only a small number of patients discontinued treatment and the mean doses used were arguably significantly different.

Second, Undurraga et al suggest functional outcomes could also be explained by baseline differences; they mention no blinding of the primary outcome and a subjective and unreliable outcome measure (Groningen Social Disabilities Schedule II).

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