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Neuroscience and Psychiatry
July 2014

Synaptic Health

Author Affiliations
  • 1Department of Neuroscience and Friedman Brain Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York
JAMA Psychiatry. 2014;71(7):835-837. doi:10.1001/jamapsychiatry.2014.380

Cognitive decline is a common but not inevitable consequence of normal aging. Age-related declines in cognitive ability have been linked to neurobiological changes in specific brain areas that affect synaptic communication, restrict the capacity of information processing, and interfere with memory formation and retrieval. Moreover, these changes in neural function may render neurons more vulnerable to degeneration. Thus, good synaptic health may not only promote preservation of cognitive function into advanced age but also protect against neurodegenerative diseases that increase in prevalence with aging.

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