September 2014

The Many Continua of Psychosis

Author Affiliations
  • 1 Department of Psychiatry and Psychology, Maastricht University Medical Centre, South Limburg Mental Health Research, Maastricht, the Netherlands
  • 2Teaching Network, European Graduate School of Neuroscience, Maastricht, the Netherlands
  • 3King’s Health Partners, Department of Psychosis Studies, Institute of Psychiatry, King’s College London, London, England

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JAMA Psychiatry. 2014;71(9):985-986. doi:10.1001/jamapsychiatry.2014.1068

Zavos and colleagues1 present a twin study showing that individual psychotic experiences (PE) (eg, paranoia, hallucinations, and grandiosity) in the general population display heritabilities that lie between those of depression (40%) and schizophrenia (60%). More important, the same genetic and environmental influences appear to drive variation across the spectrum of PE severity, which the authors suggest may point to a continuum of psychosis.

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