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Comment & Response
August 2014

Very Small P Values—Reply

Author Affiliations
  • 1Department of Psychiatry, Washington University in St Louis, St Louis, Missouri
  • 2University of Southern California, Los Angeles
JAMA Psychiatry. 2014;71(8):969. doi:10.1001/jamapsychiatry.2014.707

In Reply Our study showed that, among individuals with severe mental illness, the rates of tobacco, alcohol, and other substance use are dramatically higher than in the general population.1 The criticisms made by Knapp and Hayat highlight long-standing statistical controversies: effect size vs P value and proper adjustment for confounding variables.

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