Patients treated with interferon alfa are frequently subject to mood disorders.1 This report describes 2 cases of mania subsequent to withdrawal of treatment with interferon alfa observed during a prospective study of a cohort of 44 patients affected by chronic hepatitis B receiving long-term treatment. Both subjects had normal findings on personal and family histories for psychiatric disorders.
Carpiniello B, Orrù MG, Baita A, Pariante CM, Farci G. Mania Induced by Withdrawal of Treatment With Interferon Alfa. Arch Gen Psychiatry. 1998;55(1):88-89. doi: