To the Editor Rasetti and colleagues1 wrote a stimulating article that highlighted the major role played by the hippocampal complex (HC; ie, the hippocampus and parahippocampal gyri) in the pathophysiology of schizophrenia. The authors claimed that patients with schizophrenia and their healthy siblings exhibited reduced bilateral parahippocampal activity and hippocampal-parietal (BA 40) coupling during the encoding of novel stimuli when compared with matched healthy control individuals. The authors indicated that these findings may support the potential role of the hippocampal-parahippocampal function during encoding as an intermediate biological phenotype related to an increased genetic risk for schizophrenia.
Amad A, Thomas P, Jardri R. The Hippocampal Complex at the Crossroad of Dimensional/Categorical Approaches. JAMA Psychiatry. 2014;71(9):1077. doi:10.1001/jamapsychiatry.2014.123