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Comment & Response
September 2014

Fixed-Effects Models and Diagnosing Psychiatric Disorders—Reply

Author Affiliations
  • 1Department of Psychological and Brain Sciences, Indiana University–Bloomington
  • 2Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
JAMA Psychiatry. 2014;71(9):1078-1079. doi:10.1001/jamapsychiatry.2014.693

In Reply We appreciate having the opportunity to respond to Sonis’ concerns regarding our article on advancing paternal age (APA) at childbearing.1 The population and within-family estimates responded to different research questions. The population estimates examined how common it is that offspring born to fathers of different ages have psychopathology. On the other hand, the comparison of differentially exposed siblings and cousins using fixed-effects models examined the magnitude of the risk for psychopathology in offspring associated with paternal age while holding other factors constant.

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