A recent essay by Carpenter et al1 was timely, thoughtful, and helpful in clarifying some issues associated with medication-free conditions in contemporary research on psychotic disorders. Several points require emphasis and comment, however. Overall, the essay reflects an ongoing struggle to balance appropriate clinical and ethical concerns with the desire to obtain sound and interpretable research data. Without sound results, the entire enterprise of clinical research would be questionable, both scientifically and ethically.
Baldessarini RJ, Viguera AC. Medication Removal and Research in Psychotic Disorders. Arch Gen Psychiatry. 1998;55(3):281-282. doi: