Rapoport et al stated in "Childhood-Onset Schizophrenia" (Arch Gen Psychiatry. 1997;54:897-903) that "the possibility that clozapine treatment accelerates adolescent brain change cannot be ruled out"(p902) as a cause of brain abnormalities found on magentic resonance imaging studies. All the children diagnosed schizophrenic in this study were also participating in a double-blind comparison study of haloperidol and clozapine therapy. At a 2-year prospective follow-up study 12 patients were taking clozapine and the remaining 4 were taking risperidone. In addition, many patients were taking multiple psychiatric medications.
Breggin PR. Does Clozapine Treatment Cause Brain Disease?. Arch Gen Psychiatry. 1998;55(9):845. doi: