December 1998

Treating Major Depression in Primary Care PracticeAn Update of the Agency for Health Care Policy and Research Practice Guidelines

Author Affiliations

From the Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pa (Dr Schulberg); Department of Psychiatry and Behavioral Sciences, University of Washington Medical School (Drs Katon and Simon), and Center for Health Studies, Group Health Cooperative (Dr Simon), Seattle, Wash; and Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas (Dr Rush).


Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

Arch Gen Psychiatry. 1998;55(12):1121-1127. doi:10.1001/archpsyc.55.12.1121

The Depression Guideline Panel of the Agency for Health Care Policy and Research in 1993 published recommendations for treating major depression in primary care practice that were often based on studies of tertiary care psychiatric patients. We reviewed reports of randomized controlled trials in primary care settings published between 1992 and 1998. This evidence indicates that both antidepressant pharmacotherapy and time-limited depression-targeted psychotherapies are efficacious when transferred from psychiatric to primary care settings. In most cases, the choice between these treatments should depend on patient preference. Studies to date suggest that improving treatment of depression in primary care requires properly organized treatment programs, regular patient follow-up, monitoring of treatment adherence, and a prominent role for the mental health specialist as educator, consultant, and clinician for the more severely ill. Future research should focus on how guidelines are best implemented in routine practice, since conventional dissemination strategies have little impact.