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Letters to the Editor
January 1999

No Allelic Association Between Bipolar Affective Disorder and the Tryptophan Hydroxylase Gene—Reply

Arch Gen Psychiatry. 1999;56(1):101. doi:

In reply

We reported a positive association between the intron 7 A218C polymorphism of the TPH gene and bipolar affective disorder in a sample of 158 bipolar patients (103 with bipolar I and 49 with bipolar II) and 94 controls.1 However, 2 subsequent studies failed to confirm this finding. Kirov et al2 show no preferential A218C allele transmission in a sample of 118 parent-offspring trios and McQuillin et al3 failed to replicate the initial finding in a case-control association study.

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