Clozapine is the only antipsychotic agent with proven efficacy in treatment-resistant schizophrenia1; however, a substantial minority of patients fail to respond or have only a partial response to clozapine, leading clinicians to search for potential augmentation strategies to improve outcomes. To date, these augmentation strategies with clozapine have generally been disappointing.
Dursun SM, McIntosh D, Milliken H. Clozapine Plus Lamotrigine in Treatment-Resistant Schizophrenia. Arch Gen Psychiatry. 1999;56(10):950. doi:10.1001/archpsyc.56.10.950