In the November 2000 issue of the ARCHIVES, Meston and Frohlich1 provided a review of the past and current literature
on the neurobiology of sexual function. We would like to add some facts about
luteinizing hormone–releasing hormone (LH-RH) agonists. Experiences
with LH-RH agonists have suggested that they might also be helpful in the
treatment of paraphilias, especially in connection with sexual offending.
Luteinizing hormone–releasing hormone agonists inhibit the production
of testosterone by overwhelming the pulsatile stimulation of the pituitary
gland by constant stimulation.
Briken P. Pharmacotherapy of Paraphilias With Luteinizing Hormone–Releasing Hormone Agonists. Arch Gen Psychiatry. 2002;59(5):469-470. doi: