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Letters to the Editor
May 2002

Pharmacotherapy of Paraphilias With Luteinizing Hormone-Releasing Hormone Agonists

Arch Gen Psychiatry. 2002;59(5):470. doi:

In reply

Drs Briken, Nika, and Berner add an important point to the discussion of the neurobiology of sexual function. The Meston and Frohlich1 article discussed sexual drive from the perspective of normal sexual drive, inhibited sexual drive, and treatments designed to increase sexual drive. The main conclusion was that testosterone is not associated with sexual drive in males unless testosterone levels falls below a critical level, as often seen with hypogonadal men. A review of medications known to reduce sexual drive and their mechanism of action certainly adds to this discussion. Indeed, it is well established that luteinizing hormone–releasing hormone (LH-RH) agonists reduce sexual drive, as noted by their effects on men taking them as treatment for benign prostatic hyperplasia.2

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