Copyright 2006 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2006
Although dozens of genes have been linked to psychiatric disorders, connecting the dots between behavioral phenotypes and genetic variations has not been easy. In this issue of the Archives, 2 groups of investigators report that statistically significant associations between the transmission of obsessive-compulsive disorder (OCD) for male but not female offspring, and a genetic locus on chromosome 9p24 that codes for a high-affinity neuronal/epithelial excitatory amino acid transporter (ECCA-1) known in the genetic world as SLC1A1 (solute carrier family 1, member 1; Online Mendelian Inheritance in Man [OMIM] 133550).1,2 In the brain, this transporter is crucial in terminating the action of the excitatory neurotransmitter glutamate and in maintaining extracellular glutamate concentrations within a normal range.
Leckman JF, Kim Y. A Primary Candidate Gene for Obsessive-compulsive Disorder. Arch Gen Psychiatry. 2006;63(7):717-720. doi:10.1001/archpsyc.63.7.717