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Comment & Response
April 2015

Childhood Trauma–Specific Reductions in Limbic Gray Matter VolumeStill in the Dark

Author Affiliations
  • 1Department of Psychiatry, University Medical Center Utrecht and Brain Center Rudolf Magnus, Utrecht, the Netherlands
JAMA Psychiatry. 2015;72(4):398. doi:10.1001/jamapsychiatry.2014.2680

To the Editor In their article, Van Dam and colleagues1 reported a unique association between childhood maltreatment (CM) and decreased gray matter volumes (GMVs) in the left limbic regions, both in individuals with substance use disorder and in healthy control individuals. By disentangling the separate influences of CM and psychopathology on GMV, the authors make an important contribution as literature on the specific effects of CM in the absence of psychopathology has been scarce and inconsistent. However, their conclusion that the GMV reductions found in the left limbic regions are uniquely associated with CM may be a bit premature.

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