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Comment & Response
May 2015

Anti-inflammatory Intervention in Depression

Author Affiliations
  • 1Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia
  • 2Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles
JAMA Psychiatry. 2015;72(5):511. doi:10.1001/jamapsychiatry.2014.3128

To the Editor We acknowledge the important work published by Köhler et al.1 This meta-analysis explored the clinical antidepressant effects of anti-inflammatories. The article found 14 randomized clinical trials and noted anti-inflammatory treatments (nonsteroidal anti-inflammatory drugs and cytokine inhibitors) reduce depressive symptoms vs placebo. The authors stated that the findings provide a proof of concept concerning anti-inflammatory treatments in depression; however, a high risk for bias and heterogeneity was noted.

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