In the last century, the following 2 concepts have guided our thinking about schizophrenia: schizophrenia as a neurodevelopmental disorder and disconnection syndrome. Although past examinations of developmental trajectories as premorbid antecedents have focused on gray matter, altered properties of white matter and connectivity have been gaining more attention in the pathophysiology of schizophrenia. Several studies, including a JAMA Psychiatry article,1 are beginning to illuminate the nature, timing, and clinical consequences of alterations in such developmental trajectories. Thus, the 2 concepts are coming together.
Keshavan MS, Paus T. Neurodevelopmental Trajectories, Disconnection, and Schizophrenia Risk. JAMA Psychiatry. 2015;72(9):943-945. doi:10.1001/jamapsychiatry.2015.1119