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Comment & Response
October 2015

Estimating Mortality Associated With Antipsychotics and Other Psychotropics—Reply

Author Affiliations
  • 1Department of Psychiatry, University of Michigan, Ann Arbor
  • 2Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, Michigan
  • 3Department of Psychiatry, University of Southern California, Los Angeles
JAMA Psychiatry. 2015;72(10):1058. doi:10.1001/jamapsychiatry.2015.0675

In Reply Dr Lozano suggests that in our article,1 we failed to take into account the variation in depression prevalence between the various medication user groups and matched nonusers and that our findings were therefore biased.

However, the multivariable logistic regression models we used to estimate the 180-day mortality risk included depression (see Tables 2 and 3 of our article).1 By including depression and other clinical variables listed in the table footnotes in the regression models, we controlled for the variation in characteristics between medication users and nonusers (eg, difference in depression prevalence), allowing us to isolate the association of a particular medication with mortality.

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