In Reply I wholeheartedly agree with the main point made by Meinlschmidt et al that well-justified, well-designed, and well-executed (non–poorly justified, designed, or executed [PJDE]) randomized clinical trials warrant dissemination—statistically significant or not. Crucial is whether a randomized clinical trial advances knowledge. It is the responsibility of reviewers and readers to evaluate the quality and value of every study (exploratory or hypothesis testing, statistically significant or not) before making decisions.
Kraemer HC. Disseminating Justified, Well-Designed, and Well-Executed Studies With Nonsignificant Tests—Reply. JAMA Psychiatry. 2016;73(1):89-90. doi:10.1001/jamapsychiatry.2015.2301