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Comment & Response
March 2016

Sibling Comparisons and Confounding in Autism Epidemiological Studies—Reply

Author Affiliations
  • 1The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Department of Obstetrics and Gynaecology, University College Cork, Cork, Ireland
  • 2Department of Epidemiology and Public Health, University College Cork, Cork, Ireland
JAMA Psychiatry. 2016;73(3):303. doi:10.1001/jamapsychiatry.2015.2882

In Reply We published a study on mode of delivery, more specifically birth by cesarean section (CS), and the development of autism spectrum disorder (ASD).1 In it, we found that CS was associated with ASD in the population. However, the association was attenuated when we used a sibling design, and we concluded that CS was likely not a cause of ASD and a more probable explanation of the association was confounding.

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