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To the Editor In their analysis of the National Health and Nutrition Survey (NHANES), Jokela and colleagues1 address a timely question: Is systemic inflammation more strongly associated with particular depressive symptoms? While C-reactive protein (CRP) was positively associated with all 9 depressive symptoms in separate models, it was associated with only sleep disturbance, fatigue, and appetite changes in models adjusting for the other 8 symptoms. Because these associations are likely bidirectional,2,3 this line of research has the potential to (1) clarify the pathophysiology of inflammation-related depression and inform the development of new depression interventions targeting inflammation and (2) elucidate the mechanisms through which depression increases cardiometabolic disease risk and inform the development of new primary prevention approaches.
Stewart JC. One Effect Size Does Not Fit All—Is the Depression-Inflammation Link Missing in Racial/Ethnic Minority Individuals?. JAMA Psychiatry. 2016;73(3):301-302. doi:10.1001/jamapsychiatry.2015.3205