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To the Editor Methodological considerations raised by Lord and Veenstra-VanderWeele1 regarding genotype-first approaches to phenotype research are appreciated. In their editorial focusing on autism spectrum disorder, the authors described the importance of considering phenotypic confounds. This letter expands on these considerations with discussion of novel methods increasingly used for predicting and classifying psychiatric phenotypes from genetic data. These developing methods may be further useful in resolving confounds.
Docherty AR. Genomic Approaches to Phenotype Prediction. JAMA Psychiatry. 2016;73(5):536. doi:10.1001/jamapsychiatry.2016.0031