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May 2016

Predicting Schizophrenia

Author Affiliations
  • 1Departments of Psychiatry, Psychology, and Neuroscience, Duke University Medical Center, Durham, North Carolina
  • 2Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York
JAMA Psychiatry. 2016;73(5):441-442. doi:10.1001/jamapsychiatry.2016.0138

Our ability to predict who will develop schizophrenia is at its nascent stages. No genes of major effect have been identified. Studies of care-seeking individuals who are at high risk based on the presence of certain symptoms and functional or cognitive manifestations are able to predict with 35% likelihood the onset of psychosis within the next year or 2,1 but early detection and disease prediction is unachievable in most cases.

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