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Bipolar disorder (BD) is a severe mental disorder characterized by alternating periods of depression and mania. It is a highly heritable disorder, and the underlying etiology is thought to be largely genetic, although the identification of specific causal variants has remained challenging. In this issue of JAMA Psychiatry, Goes et al1 used a 2-stage analysis to first identify variants that segregate within families enriched for bipolar and related disorders (BD-I, BD-II, and schizoaffective disorder, bipolar type) and subsequently tested for association of these variants in 3 independent case-control studies.
Kember RL, Bućan M. Promising 2-Pronged Approach to Genetic Basis of Bipolar Disorder. JAMA Psychiatry. 2016;73(6):553-554. doi:10.1001/jamapsychiatry.2016.0298