In Reply The letter by Hengartner raised important issues regarding the significance and interpretation of findings in our recent meta-analysis1 on the association of increasing age at menopause and duration of reproductive period with decreased risk for depression in postmenopausal women. While we value the concerns, the following points should be underlined.
Georgakis MK, Skalkidou A, Petridou ET. Estrogen-Based Therapies and Depression in Women Who Naturally Enter Menopause Before Population Average—Reply. JAMA Psychiatry. 2016;73(8):874-875. doi:10.1001/jamapsychiatry.2016.0953