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Comment & Response
August 2016

Estrogen-Based Therapies and Depression in Women Who Naturally Enter Menopause Before Population Average—Reply

Author Affiliations
  • 1Department of Hygiene, Epidemiology, and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
  • 2Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden

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JAMA Psychiatry. 2016;73(8):874-875. doi:10.1001/jamapsychiatry.2016.0953

In Reply The letter by Hengartner raised important issues regarding the significance and interpretation of findings in our recent meta-analysis1 on the association of increasing age at menopause and duration of reproductive period with decreased risk for depression in postmenopausal women. While we value the concerns, the following points should be underlined.

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