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Comment & Response
October 2016

Use of Clozapine in Schizophrenia

Author Affiliations
  • 1Northamptonshire Healthcare NHS Foundation Trust, Northampton, England
JAMA Psychiatry. 2016;73(10):1097. doi:10.1001/jamapsychiatry.2016.0976

To the Editor Clozapine was not shown to be superior to other antipsychotic drugs in the comprehensive meta-analysis conducted by Samara et al.1 This finding is in stark contrast to the landmark randomized clinical trial by Kane et al,2 which has been backed by the cumulative wisdom of nearly 3 decades of clinical experience and observational evidence.

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