To the Editor Clozapine was not shown to be superior to other antipsychotic drugs in the comprehensive meta-analysis conducted by Samara et al.1 This finding is in stark contrast to the landmark randomized clinical trial by Kane et al,2 which has been backed by the cumulative wisdom of nearly 3 decades of clinical experience and observational evidence.
Mustafa FA. Use of Clozapine in Schizophrenia. JAMA Psychiatry. 2016;73(10):1097. doi:10.1001/jamapsychiatry.2016.0976