To the Editor With rapidly shifting legislation worldwide in relation to recreational and medicinal cannabis use, the review by Volkow et al1 is timely. We highlight several additional noteworthy issues for consideration.
While further evidence has emerged that acute and long-term exposure to cannabis impairs cognition,2 there is still grossly insufficient evidence for recovery of function with abstinence. Neither the parameters of cannabis exposure nor the neural mechanisms subserving persistence or recovery have been elucidated. Well-controlled prospective studies monitoring restoration of brain function and structure from current use through prolonged abstinence are required to delineate the time course and moderators of potential recovery of cognitive function.
Solowij N, Lorenzetti V, Yücel M. Effects of Cannabis Use on Human BehaviorA Call for Standardization of Cannabis Use Metrics. JAMA Psychiatry. 2016;73(9):995-996. doi:10.1001/jamapsychiatry.2016.1329