Prolonged duration of untreated psychosis (DUP) is associated with poorer outcomes across multiple health care systems.1 Early detection (ED) efforts can reduce these delays2 but face a challenge: typically skewed DUP distributions are poorly managed by commonly used statistical methods. This limits the strength and scope of inferences about ED’s effectiveness.1 Also, while reducing DUP will improve outcomes for most patients, there are some for whom a particularly long DUP is a byproduct of an insidiously unfolding illness rather than a modifiable prognostic factor.3 This highlights the need for a tool to interrogate the effect of ED across the full range of DUP.
Guloksuz S, Li F, Tek C, Woods SW, McGlashan TH, Friis S, Srihari VH. Analyzing the Duration of Untreated PsychosisQuantile Regression. JAMA Psychiatry. 2016;73(10):1094-1095. doi:10.1001/jamapsychiatry.2016.2013