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Research Letter
October 2016

Analyzing the Duration of Untreated PsychosisQuantile Regression

Author Affiliations
  • 1Department of Psychiatry and Psychology, Maastricht University Medical Centre, Maastricht, the Netherlands
  • 2Yale Center for Analytical Science, Yale School of Public Health, New Haven, Connecticut
  • 3Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut
  • 4Institute of Clinical Medicine, University of Oslo, Oslo, Norway
JAMA Psychiatry. 2016;73(10):1094-1095. doi:10.1001/jamapsychiatry.2016.2013

Prolonged duration of untreated psychosis (DUP) is associated with poorer outcomes across multiple health care systems.1 Early detection (ED) efforts can reduce these delays2 but face a challenge: typically skewed DUP distributions are poorly managed by commonly used statistical methods. This limits the strength and scope of inferences about ED’s effectiveness.1 Also, while reducing DUP will improve outcomes for most patients, there are some for whom a particularly long DUP is a byproduct of an insidiously unfolding illness rather than a modifiable prognostic factor.3 This highlights the need for a tool to interrogate the effect of ED across the full range of DUP.

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