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Comment & Response
October 2016

Hyperthermia for Major Depressive Disorder?

Author Affiliations
  • 1Stony Brook University School of Medicine, Saint James, New York
  • 2University of Toronto, Medicine, History of Medicine Program, Toronto, Ontario, Canada
JAMA Psychiatry. 2016;73(10):1096. doi:10.1001/jamapsychiatry.2016.1627

To the Editor The study by Janssen et al1 of a single exposure to whole-body hyperthermia relieving major depressive disorder is difficult to interpret and will need replication. The participants were highly selected from among long-time ill individuals with modest scores on the 17-item Hamilton Depression Rating Scale having less than 40% reduction with treatment. Which form of depression in the pool of “major depression” may be responsive to hyperthermia?

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