The article in this issue of JAMA Psychiatry by Seidman et al1 presents an important series of findings related to cognitive impairment associated with psychosis. As part of the second phase of the North American Prodrome Longitudinal Study,2 this study systematically investigates neuropsychological functioning in individuals at clinical high risk for psychosis. The results provide a new reference point for clinicians and researchers by elucidating the profile of neurocognitive deficits associated with the prodrome as well as their potential as risk markers for conversion to clinical psychosis.1 The study also raises several questions that the field will need to address.
Reichenberg A, Mollon J. Challenges and Opportunities in Studies of Cognition in the Prodrome to PsychosisNo Detail Is Too Small. JAMA Psychiatry. Published online November 02, 2016. doi:10.1001/jamapsychiatry.2016.2655