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Original Investigation
November 30, 2016

Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology

Author Affiliations
  • 1Division of Child and Adolescent Psychiatry, Department of Psychiatry, University of Colorado, Anshutz Medical Campus, Aurora
  • 2Section on Bipolar Spectrum Disorders, Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland
  • 3Department of Psychology, University of Denver, Denver, Colorado
  • 4Scientific and Statistical Computing Core, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland
  • 5currentlywith Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill
  • 6Section on Development and Affective Neuroscience, Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland
JAMA Psychiatry. Published online November 30, 2016. doi:10.1001/jamapsychiatry.2016.3282
Key Points

Question  How does the brain respond to facial emotions signifying threat in youths with pathologic anxiety and/or irritability?

Findings  In this functional magnetic resonance imaging study of 115 participants, anxiety and irritability were jointly associated with the amygdala’s connectivity to regulatory regions in the prefrontal cortex during face emotion processing. In particular, when participants viewed very angry faces, high irritability and high anxiety were associated with increased amygdala–medial prefrontal cortex connectivity, while high irritability and low anxiety were associated with decreased connectivity in the same circuit.

Meaning  Anxiety and irritability appear to interact to influence connectivity in the neural system mediating response to social threat.

Abstract

Importance  Psychiatric comorbidity complicates clinical care and confounds efforts to elucidate the pathophysiology of commonly occurring symptoms in youths. To our knowledge, few studies have simultaneously assessed the effect of 2 continuously distributed traits on brain-behavior relationships in children with psychopathology.

Objective  To determine shared and unique effects of 2 major dimensions of child psychopathology, irritability and anxiety, on neural responses to facial emotions during functional magnetic resonance imaging.

Design, Setting, and Participants  Cross-sectional functional magnetic resonance imaging study in a large, well-characterized clinical sample at a research clinic at the National Institute of Mental Health. The referred sample included youths ages 8 to 17 years, 93 youths with anxiety, disruptive mood dysregulation, and/or attention-deficit/hyperactivity disorders and 22 healthy youths.

Main Outcomes and Measures  The child’s irritability and anxiety were rated by both parent and child on the Affective Reactivity Index and Screen for Child Anxiety Related Disorders, respectively. Using functional magnetic resonance imaging, neural response was measured across the brain during gender labeling of varying intensities of angry, happy, or fearful face emotions. In mixed-effects analyses, the shared and unique effects of irritability and anxiety were tested on amygdala functional connectivity and activation to face emotions.

Results  The mean (SD) age of participants was 13.2 (2.6) years; of the 115 included, 64 were male. Irritability and/or anxiety influenced amygdala connectivity to the prefrontal and temporal cortex. Specifically, irritability and anxiety jointly influenced left amygdala to left medial prefrontal cortex connectivity during face emotion viewing (F4,888 = 9.20; P < .001 for mixed model term). During viewing of intensely angry faces, decreased connectivity was associated with high levels of both anxiety and irritability, whereas increased connectivity was associated with high levels of anxiety but low levels of irritability (Wald χ21 = 21.3; P < .001 for contrast). Irritability was associated with differences in neural response to face emotions in several areas (F2, 888 ≥ 13.45; all P < .001). This primarily occurred in the ventral visual areas, with a positive association to angry and happy faces relative to fearful faces.

Conclusions and Relevance  These data extend prior work conducted in youths with irritability or anxiety alone and suggest that research may miss important findings if the pathophysiology of irritability and anxiety are studied in isolation. Decreased amygdala–medial prefrontal cortex connectivity may mediate emotion dysregulation when very anxious and irritable youth process threat-related faces. Activation in the ventral visual circuitry suggests a mechanism through which signals of social approach (ie, happy and angry expressions) may capture attention in irritable youth.

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