Chronic depression is one of the most challenging types of the major depressive disorders to treat, as many patients with chronic depression are resistant to several treatments, leaving clinicians with no or few treatment options available. From a public health perspective, chronic depressive disorders are also problematic because they are responsible for a considerable part of the disease burden of depression. The development of effective treatments for chronic depression is therefore one of the most important challenges for clinical research in depression.
Cuijpers P, Huibers MJH, Furukawa TA. The Need for Research on Treatments of Chronic Depression. JAMA Psychiatry. 2017;74(3):242-243. doi:10.1001/jamapsychiatry.2016.4070