Meta-analyses are definitely en vogue. A quick PubMed search using the key words “schizophrenia and meta-analysis” shows results that increase from 22 to 149 and 301 from 1996 to 2006 and 2016. Restricting the search to “schizophrenia and treatment and meta-analysis” yielded 13 results that grew to 86 and 140. In this issue of JAMA Psychiatry, Correll et al1 provide a new take on this development by subjecting 29 meta-analyses on cotreatment strategies added to antipsychotic monotherapy in schizophrenia to a “meta-meta-analysis.” Irrespective of the results of their undertaking, in which they refute findings from an earlier report that they authored,2 their novel approach and the value of meta-analyses warrant commentary.
Fleischhacker WW. A Meta View on Meta-analyses. JAMA Psychiatry. Published online May 17, 2017. doi:10.1001/jamapsychiatry.2017.1167