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Letters to the Editor
March 2000

Dextromethorphan Challenge in Alcohol-Dependent Patients and Controls—Reply

Arch Gen Psychiatry. 2000;57(3):292. doi:

In reply

We thank Drs Schütz and Soyka for their interest in our article.1 We appreciate their sharing data consistent with the hypothesis that N-methyl-D-aspartate (NMDA) antagonist actions of ethanol contribute to its subjective effects and its abuse potential. Their data also suggested that dextromethorphan effects were blunted in patients.

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