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Letters to the Editor
May 2000

Testing for Laterality Differences in Regional Brain Volumes

Arch Gen Psychiatry. 2000;57(5):511. doi:10.1001/archpsyc.57.5.511

In their meta-analysis of magnetic resonance imaging studies of schizophrenia, Nelson et al1 report that schizophrenia was significantly associated with bilaterally reduced hippocampal volumes and that no laterality differences were seen. The absence of laterality differences is important in providing evidence against those theories of the pathogenesis of schizophrenia that postulate that brain changes are predominantly left-sided.2

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