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Letters to the Editor
June 2000

Hippocampal and Superior Temporal Gyrus Volume in First-Episode Schizophrenia

Author Affiliations

Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2000

Arch Gen Psychiatry. 2000;57(6):618. doi:

The article by Velakoulis et al1 reported the important finding of hippocampal volume reduction in first-episode schizophrenia and interpreted it as evidence in support of a neurodevelopmental model of this disorder. The authors stated that "no [previous] studies have examined the specificity of this finding to first-episode schizophrenia, compared with first-episode affective psychosis."1(p133) Probably because their article was in press (it was accepted for publication on October 2, 1998), Velakoulis and coworkers did not cite our report2 in the October 1998 issue of the American Journal of Psychiatry, which, to our knowledge, was the first published report of lack of specificity of hippocampal volume reduction in first-episode schizophrenia relative to first-episode affective psychosis. Our study used a spoiled gradient-recalled acquisition protocol, resulting in 124 contiguous 1.5-mm coronal slices, to evaluate the hippocampus in 17 patients with first-episode schizophrenic psychosis compared with 16 first-episode affective psychosis patients and 18 normal control subjects. The first-episode schizophrenic patients showed significant volume reduction in the left, but not right, hippocampus, compared with control subjects. Moreover, left hippocampal volume in first-episode affective patients did not differ statistically from first-episode schizophrenic patients or normal subjects. Additionally, in our study, both patients with first-episode schizophrenic and affective psychosis demonstrated left less than right asymmetry of hippocampal volume, while controls showed no such asymmetry. We think that the similarity between our findings and those reported by Velakoulis and colleagues reinforce each other in the conclusion that hippocampal volume abnormalities may not be specific to first-episode schizophrenia as compared with affective disorder.

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