We thank Hirayasu and colleagues for their letter in response to our article on hippocampal volumes in patients with first-episode psychosis.1 We note that their first-episode study2 also examined patients with first-episode psychosis and included patients with schizophrenia/schizophreniform and affective psychosis. Few studies to date have examined the specificity of brain structural abnormalities to schizophrenia and no previous studies using high-resolution images have examined this issue.
Velakoulis D, McGorry P, Copolov D, Pantelis C. Hippocampal and Superior Temporal Gyrus Volume in First-Episode Schizophrenia. Arch Gen Psychiatry. 2000;57(6):618-619. doi: