[Skip to Content]
[Skip to Content Landing]
Letters to the Editor
August 2000

Fluvoxamine Strongly Inhibits Melatonin Metabolism in a Patient With Low-Amplitude Melatonin Profile

Arch Gen Psychiatry. 2000;57(8):812-813. doi:10.1001/archpsyc.57.8.812

Fluvoxamine maleate increases early morning concentrations of melatonin in humans.1,2 The serotonin reuptake inhibitor was therefore assumed to enhance the melatonin production by providing a precursor surplus of serotonin. Alternatively, fluvoxamine might inhibit the melatonin metabolism. The following case report strongly supports the second hypothesis.

First Page Preview View Large
First page PDF preview
First page PDF preview