Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2000
In the January 1999 issue of the ARCHIVES, Farber et al1 commented on 2 recent clinical trials of glycinergic agents used to treat schizophrenia. The commentary, overall, supported the concept that underactivity of N-methyl-D-aspartate (NMDA) receptor–mediated neurotransmission may play a crucial role in the pathophysiology of schizophrenia. However, we feel it is important to discuss 3 specific issues raised in that commentary.
Javitt DC, Heresco-Levy U. Are Glycine Sites Saturated In Vivo?. Arch Gen Psychiatry. 2000;57(12):1181-1183. doi: