IN THIS issue, Penninx et al1 report the results of a longitudinal study of depression as a risk factor for cardiac mortality in elderly, community-dwelling residents of Amsterdam, the Netherlands. This study joins a growing number of methodologically sound investigations showing that depression increases the risk of cardiac mortality, yet some fundamental questions remain about depression as a cardiovascular risk factor. Their study addresses 2 such questions that have both mechanistic and clinical relevance.
Carney RM, Freedland KE, Jaffe AS. Depression as a Risk Factor for Coronary Heart Disease Mortality. Arch Gen Psychiatry. 2001;58(3):229–230. doi:10.1001/archpsyc.58.3.229