Harlow et al1 recently published data from a study describing prevalence and predictors of depression in older premenopausal women. The study describes a significant rate (22.4%) of current depressive symptoms (defined as Center for Epidemiologic Studies Depression Scale [CES-D]2 score >16) in a cross-sectional population-based study. It also describes a significant association between past or current depression and a higher risk for depressive symptoms and premenstrual complaints, particularly among women with significant premenstrual functioning impairment.
de Novaes Soares C, Almeida OP. Depression During the Perimenopause. Arch Gen Psychiatry. 2001;58(3):306. doi: