In an elegant study recently published in the ARCHIVES, Raine et al%1 demonstrated a significant (11%) reduction in prefrontal gray but not white matter in antisocial personality disorder (APD). Reduced prefrontal gray matter volume in the subjects with APD was related to reduced autonomic arousal in association with a social stressor. Raine et al%1 discussed their findings as supporting the presence of prefrontal deficits that may underlie the social and moral impoverishment observed in APD.
Bigler ED. Frontal Lobe Pathology and Antisocial Personality Disorder. Arch Gen Psychiatry. 2001;58(6):609-611. doi: