I was pleased to read the analysis by Baldessarini and Tondo1 indicating that, contrary to some reports, lithium has not lost its efficacy as a treatment for bipolar disorder in recent years. Certainly their findings are in accord with my own clinical experience that lithium is effective and well tolerated, especially at moderate serum lithium concentrations, as they note in their report.
Rosenthal NE. Lithium: An Orphan Drug. Arch Gen Psychiatry. 2001;58(10):973. doi:10.1001/archpsyc.58.10.973