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Letters to the Editor
May 2008

Meta-analysis of Brain Volumes in Unaffected First-Degree Relatives of Patients With Schizophrenia Overemphasizes Hippocampal Deficits

Arch Gen Psychiatry. 2008;65(5):603-604. doi:10.1001/archpsyc.65.5.603

We read with interest the important meta-analysis of brain volumes in unaffected first-degree relatives of patients with schizophrenia by Boos and colleagues.1 Given the highly influential status of meta-analysis in the hierarchy of evidence, methodological rigor in carrying out a meta-analysis is paramount. However, we note several apparent errors and question the authors' conclusion that brain abnormalities in such relatives are “most pronounced in the hippocampus.”

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