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Letters to the Editor
November 3, 2008

Child Abuse and Adult Major Depression: No Evidence of Protective Gene—Reply

Arch Gen Psychiatry. 2008;65(11):1337-1339. doi:10.1001/archpsyc.65.11.1337

In reply

Dr Carroll raises issues with every aspect of our article “Influence of Child Abuse on Adult Depression: Moderation by the Corticotropin-Releasing Hormone Receptor Gene.”1 While some of the issues raised are reasonable, these were previously acknowledged in the limitations section of the article. We also believe (as supported later) that many of Dr Carroll's other comments are incorrect interpretations of the article or represent a skewed and biased perspective.

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