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Dr Carroll raises issues with every aspect of our article “Influence of Child Abuse on Adult Depression: Moderation by the Corticotropin-Releasing Hormone Receptor Gene.”1 While some of the issues raised are reasonable, these were previously acknowledged in the limitations section of the article. We also believe (as supported later) that many of Dr Carroll's other comments are incorrect interpretations of the article or represent a skewed and biased perspective.
Ressler KJ, Bradley RG, Cubells JF, Binder EB. Child Abuse and Adult Major Depression: No Evidence of Protective Gene—Reply. Arch Gen Psychiatry. 2008;65(11):1337-1339. doi:10.1001/archpsyc.65.11.1337