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Letters to the Editor
July 2009

Questionable Efficacy for Naltrexone in Patients With Asp40—Reply

Arch Gen Psychiatry. 2009;66(7):796-797. doi:10.1001/archgenpsychiatry.2009.69

In reply

We thank Dr Mattes for his thoughts about our study that reported an interaction of the μ-opiate receptor polymorphism Asn40Asp with naltrexone on treatment response in alcohol dependence.1 Because the field is early in investigating the effect of this polymorphism on alcohol effects and on its pharmacogenetic interactions, there is ample room for thoughtful dialogue.

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